The U.S. Bone Graft Substitutes Market Size is Anticipated to Exceed USD 1598.1 Million by 2033, Growing at a CAGR of 5.39% from 2023 to 2033. Bone graft substitutes are biologics and can be used as an alternative to autologous bone grafts. The substitutes include allograft, demineralized bone matrix, polymers, hydroxyapatite, and several others.